Polyethylene glycol - modified nanocarrier encapsulation of Diminazene aceturate improved haematobio- chemical recovery in Trypanosoma brucei brucei infected rats

The enhanced safe drug delivery properties of polyethylene glycol (PEG) – modified Diaminazene aceturate nanocomposite against Trypanosoma brucei infected rats were evaluated. The drug conjugation was carried out by adding gold nanoparticle to PEG and diminazene aceturate. A group of infected rats were treated with free diaminazene aceturate, while other groups were treated with conjugated drug at different drug release time interval. Results revealed complete parasite clearance on day 4 and 6 post infection for rats treated with free drug and nano-formulated drug at 3–15 minutes release time. Rats treated with three minutes drug release shows satisfactory serum and liver enzyme activities as well as high RBC counts when compared (p < 0.05) with infected untreated and infected treated with free drug. The hematatological indices of non treated rats were lower than those treated with free and nano-formulated drug. Nanoencapsulation of diminazene aceturate therefore improved drug delivery and reduced toxicity in the treatment of African trypamosomiasis