The effect of collagen degradation products (CDP) on the central dopaminergic system

Telejko E., Maćkowiak J. and Wiśniewski K.: The effect of collagen degradation products (CDP) on the central dopaminergic system. Acta Physiol. Pol. The effect of collagen degradation products (CDP I - molecular weight circa 3000 D and CDP II - molecular weight circa 1200 D) on the central dopaminergic system was studied. Differences in the action of both these fractions in the apomorphine stereotypy test were noted; CDP I administered to rats in a dose of 5 µg just before application of the drug inducing the stereotypy enhanced the stereotypic behaviour of the animals whereas a dose of µg40 significantly inhibited such behaviour. CDP II, on the other hand, had no effect on this type of stereotypy. Both fractions given in doses of 15 and 40 µg enhanced the stereotypy induced by amphetamine. CDP I and CDP II (15 and 40 µg) administered 30 min before observation of the animals intensified the cataleptic action of haloperidol, whereas both fractions (CDP I and CDP II) when administered 45 min before observation reduced the catalepsy.