Fluorometric Determination of Stability Constants of Inclusion Complexes of Naproxen and Charged Cyclodextrins in Aqueous Solutions. Nonlinear vs Linear Data Processing

Stability constants of complexes of naproxen with monoamino-_-cyclodextrin and carboxymethyl-_-cyclodextrin in both acidic and basic solution have been determined by fluorometry and compared with those of parent _-cyclodextrin. It appeared that a charged group linked to the cyclodextrin rim decreased its complexing ability. For determination of the stability constants, nonlinear fitting has been used as well as three methods, which consist in linearization of the original hyperbolic equation. These methods of data processing have been compared.