Substituent Effect on Aniline Carbonylation Reaction in the Presence of the PdCl2/Fe/I2/Py Catalytic System

A study of the effect of substituents in the aromatic ring on the aniline carbonylation reaction in the presence of the PdCl2/Fe/I2/Py catalytic system, where oxygen or nitrobenzene were used as oxidants, showed that the electronodonor substituents accelerate the aniline carbonylation reaction, when the reaction is conducted in the presence of oxygen. For nitrobenzene used as an oxidant in this reaction substituent was found to have no ef fect on the carbamate yield. The nitrobenzene reduction is the rate-determining step in the aniline carbonylation process.