Sulfonowe pochodne niektórych flawonoidów i ich właściwości

Flavonoids belong to a large group of natural compounds of substantial biological activity. Some examples are rutin and hesperidin which are widely used in medical treatment. Recent growing interest in these compounds comes of their possible application as natural antioxidant protecting against harmful action of free radicals. Moreover, flavonols could complex metal cations and some of them are used as analytical reagents [6-8]. The major reason for limited application of flavonoids is their weak solubility in water. Sulfonic derivatives of flavonoids due to the presence of sulfonic group in the molecule are well soluble in water. They form complexes with metal ions like their mother compounds and the complexation range is significantly wider than bioflavonoids. It in proposed to use quercetin-5'-sulfonic acid (QSA) (1) and sodium salt of morin-5'-sulfonic acid (NaMSA) (6) as new reagents in spectrophotometric determination of metals [18, 19]. Some of the compounds of Al, Ga and In with quercetin-5'-sulfonic acid and sodium salt of morin-5'-sulfonic acid show strong luminescence and for this reason can be used in laser technology. It has been found that sulfonic derivatives of quercetin could be an effective antidote against heavy metals - Hg(II), Cd, Pb(II) and as reported [37, 38] sodium salt of quercetin-5'-sulfonic acid (2) is a particularly active one. Sulfonic derivatives of quercetin, morin and chrysin, exhibit also the activity in different biological systems. It is supposed that sulfonic derivatives of flavonoids could have greater practical application than their mother compounds.