Research data for article: Mutual impact of adipocytes and colorectal cancer cells growing in co-culture conditions

This research aimed to shed more light on the detailed role of interactions between adipocytes and colorectal cancer (CRC) cells associated with cancer progression in the context of these alterations. In this study, CRC cells induced reprogramming of adipocytes into cancer-associated adipocytes (CAAs), which was connected with the downregulation of lipid droplet formation in CAAs and alteration in adipocyte features. CAAs showed decreased metabolism-related gene expression, phosphorylation of Akt, ERK kinases, STAT3, and lactate secretion in comparison to the control. CAAs also promoted the migration, proliferation, and lipid droplet accumulation of CRC cells. After co-culturing with adipocytes, there was a shift to the G2/M phase of the cell cycle according to the differences in cyclin expression.Thus, there are complex bidirectional interactions between adipocytes and CRC cells that may be connected with the induction of CRC cell progression.