The collection includes files related to the publication: Natalia Skrzypczak, Krystian Pyta, Wiktor Bohusz, Aleksandra Leśniewska, Maria Gdaniec, Piotr Ruszkowski, Wojciech Schilf, Franz Bartl, and Piotr Przybylski. New cascade heterocyclization strategy of the benzoquinone core of ansamycin antibiotic into benzoxazole derivatives and their anticancer potency J. Org. Chem. 2023, 88, 13, 9469–9474.
The collection is the Supplementary data to this article:
Experimental procedures, progress of the substrate conversion for heterocyclization reaction (Tables S1 and S2, Figure S18) and monitoring of the reaction mechanism (Figures S19–S22); biological data (Table S4) and assays details, copy of 1H, 13C NMR, FT-IR and ESI MS spectra (Figures S23–S88) and spectral assignments, X-ray structural details of 1a–11a (Figures S1–S17; Table S3).
The collection includes figures used in the publication: :
Fig. 1 Two-step and cascade synthetic approaches leading to new benzoxazole derivatives of GDM.
Fig. 2 Selected X-ray structures of novel ansamycins bearing benzoxazole cores: (a) 1a (CCDC 2155685); (b) 8a (CCDC 2155691); (c) 11a (CCDC 2155694).
Fig. 3 Progress of the substrate conversion [%] per unit of time [min] for 1 (black), 6 (red), 8 (purple), and 10 (green).
Fig. 4 Plausible mechanism of transformation C(17)-amine congeners of GDM into novel benzoxazole ansamycin derivatives.
The collection also included a file (References) with the list of literature used in this paper:
References - Literature cited in the publication
