Selective Approaches to α- and β-Arylated Vinyl Ethers

Polish National Agency for Academic Exchange for the Iwanowska Scholarship (No. PPN/IWA/2018/1/00009/U/00001); National Science Centre of Poland for ETIUDA No. UMO-2019/32/T/ST4/00099; University of La Rioja; “Beronia”; Projekt DEAL

We developed simple and efficient protocols for palladium-catalyzed regioselective a- and b-arylations of structurally diverse vinyl ethers. Both catalytic methods proceed under relatively mild reactions conditions applying to a broad substrate range including more complex compounds providing arylated glucal or isochromene. Lacking the common requirement of a large reagent excess, the transformations are highly economic and limiting the waste production. Results from computational studies (DFT) provided insight into the key factors determining the pronounced regioselectivities of the investigated reactions.