Tytuł pozycji:
Antisense Oligodeoxynucleotides: from the Bench to the Patient
Polish - Japan Issue
Zeszyt specjalny. Polish - Japan Issue
In recent years, the antisense strategy for cancer therapy has progressed from in vitro culturestudies, to investigations in animal models, and now to clinical studies. We describe here thecurrent state of progress toward gene-directed antisense-based cancer therapy targetingBCR/ABL oncogene, primarily from the viewpoint of initial proof-of-concepts studies in animalmodels of human leukemias and phase I clinical investigations.