Tytuł pozycji:
Relationship between changes in selected thrombotic and inflammatory factors, echocardiographic parameters and the incidence of venous thrombosis after pacemaker implantation based on our own observations
- Tytuł:
-
Relationship between changes in selected thrombotic and inflammatory factors, echocardiographic parameters and the incidence of venous thrombosis after pacemaker implantation based on our own observations
- Autorzy:
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Ząbek, Andrzej
Małecka, Barbara
Majewski, Jacek
Kotula-Horowitz, Katarzyna
Domagała, Teresa
Januszek, Rafał
Lelakowski, Jacek
Rydlewska, Anna
- Data publikacji:
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2012
- Słowa kluczowe:
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inflammatory and thrombotic factors
venous thrombosis
cardiac pacing
- Język:
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angielski
- ISBN, ISSN:
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17341922
- Prawa:
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http://creativecommons.org/licenses/by-nc-sa/4.0/legalcode.pl
Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Na tych samych warunkach 4.0 Międzynarodowa
- Dostawca treści:
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Repozytorium Uniwersytetu Jagiellońskiego
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Introduction: Thrombosis (VTh) is a rare dangerous complication of pacemaker
implantation (PM). The aim of the study was to determine the dynamics of
change in selected thrombotic and inflammatory factors after PM.
Material and methods: The study involved 81 patients (30 female, mean age:
71.1 years) with PM, divided into two groups. Group A (71 patients) consisted of
patients without VTh, whereas group B (10 patients) comprised the patients
with VTh. A transthoracic echocardiogram (TTE) and a venous ultrasound (VU)
examination were performed. The levels of D-dimers, fibrinogen, tissue factor
(TF), factor VII, plasminogen activator inhibitor-1 (PAI-1), interleukin-6 (IL-6) and
high-sensitivity C-reactive protein (hsCRP) were determined in the venous blood.
After PM, the TTE and VU examinations were repeated at 6 and 12 months, and
blood analyses were performed within 7 days after PM, and subsequently at
6 and 12 months.
Results: In 10 patients of group B, symptomatic VTh occurred at a mean time
of 13.06 months after PM. Initially, the levels of IL-6, hsCRP, D-dimers, fibrinogen,
TF, VII factor and PAI-1 were considerably higher in group B than in group A.
In all patients the levels of these factors kept on increasing for up to 7 days after
the procedure. In group A they subsequently decreased, whereas in group B they
continued to rise.
Conclusions: Increased levels of inflammatory and thrombotic factors were
observed in patients with VTh before and after PM. The factors of highest risk
of VTh occurrence were D-dimers, fibrinogen and TF.