First report on the genomic characterization of Teschovirus B3 in Jiangxi Province, China

The genus Teschovirus consists of two species, Teschovirus A and Teschovirus B, with over 19 genotypes. This study sequenced the near-complete genomes of the PTV YC2 strain, previously isolated. Comparative analyses revealed nucleotide and amino acid homologies between PTV-YC2 and other PTV strains ranging from 69.7% to 93.2% and 75.6% to 99.0%, respectively. Genetic divergence analysis of the P1, polyprotein and 2C-3CD genes confirmed that PTV-YC2 belonged to the Teschovirus B species. Phylogenetic analyses showed a close evolutionary relationship between YC2 and the HuN42 strain, the prototype of the TV-B3 genotype, leading to PTV-YC2’s categorization as TV-B3. This study is the first to document the prevalence of the TV-B3 genotype in Jiangxi Province, China.