Properties of bilayer gelatin/polycaprolactone scaffolds

In this study, nanofibrous composite scaffolds have been fabricated in order to mimic the physical architecture of native extracellular matrix. Gelatin is a good candidate to mimic the chemical composition of natural collagen. It has many integrin-binding sites for cell adhesion and differentiation, which are found in collagen. However, electrospun scaffold made of gelatin had very poor mechanical properties. Therefore, in this study, bilayer nanofibrous scaffolds made of gelatin and poly(caprolactone) were produced by sequential electrospinning. The microscopic morphology, mechanical properties and porosity of electrospun bilayer gelatin/polycaprolactone scaffold were investigated.