Postreanimacjonnye izmenenija pronicaemosti gematoencefalicheskogo bariera i ich vozmoźnoe patogeneticheskoe znachenie

Experiments were conducted on, rats, with temporary (10 min) clamoing of the thoracic vascular bundle and subsequent resuscitation to study the premeability of the blood-brain barrier (BBB) to plasma albumins and globulins and to blood plasma immunoglobulins in different stages of the postresuscitation period> Mild increase of BBB premeability was detected 3 minutes after the beginning of recirculation. Promeability increased markedly in 24 hours and continued growing by the 72nd hour. At s 1-3 hour interval in recirculation the BBB was closed. The obtained results discodse the mechanisms of the development of autoimmune cerebral disorders in on organism that experienced cardiac arrest and resuscitation.