Comparison of the effect of horse anti-dog lymphocyte globulin (Hadlg) on renal and liver transplants in dogs

Effect of Horse Anti-Dog Lymphocyte Globulin (HADIgG) on kidney and liver allotransplant survival in dogs was compared. ALIgG served as a sole immunosuppression. The agent was given i.m. in a daily dose of 15 mg/kg body weight for 15days (from—2 to +13). Significant prolongation of renal allografts survival was observed (MSTof31+12days). The same ALIgG preparation administered according to the same protocol to liver transplant recipients failed to modify the course of graft rejection.