Stężenia chloramfenikolu w tkankach świń po domięśniowym podaniu Detreomycyny

Twenty pigs, averaging 25 kg, were allocated to two groups of 10 animals each and administered 25 mg/kg chloramphenicol (Detreomycin — Polfa), group I, and 50 mg Chl/kg, group II, in a single intramuscular dose. Animals were sacrificed at 6, 18, 72, 144 and 192 hours after injection time. Samples of kidney, liver, muscles, blood and urine were analyzed for the drug residues using gas chromatographic method with a detection limit of 2—10 µg/kg. Three days after the injection of 50 mg Chl/kg residues of the drug could be detected only in some samples of urine, with the exception of tissues from injection sites where the residues of 20 µg Chl/kg were demonstrated even after 8 days of withdrawal. Samples of kidneys, urine, and muscles from the injection sites were found to be preferable target sample tissues for residue analysis of Chl in pigs and food safety evaluation.