Tytuł pozycji:
Expression of IGF1, IGF1R, and SP1 factors in HPV infected cervical cancer cells
The aim of the study was to investigate the mRNA expression levels of IGF1, IGF1R, and SP1 in cervical epithelial cells in different stages of cervical cancerogenesis using real-time PCR. The analysis indicated up-regulation of IGF1 gene expression in L- SIL and H-SIL, followed by its down-regulation in cervical cancer. Firstly, the obtained results suggest that IGF1 can be recognised asan essential factor in cervical cancerogenesis; secondly the SP1 action may be crucial for IGF1 expression.
