Deep brain stimulation of the posterior hypothalamic nucleus as an alternate therapeutic target for Parkinsons disease

The posterior hypothalamic nucleus is a major component of the ascending brainstem hippocampal synchronizing pathways. The sensorimotor integration model asserts that components of the neural circuitry in hippocampus and associated structures function in the capacity of providing voluntary motor systems with continually updated feedback on their performance relative to changing environmental (sensory) conditions. A crucial aspect of this performance is the intensity with which the motor programs are initiated and maintained. The components of the neural circuitry involved in sensorimotor integration are those underlying the production of oscillation and synchrony (theta) in the hippocampus and associated structures. The talk will present an overview of theta band oscillation and synchrony and how it led to our testing of posterior hypothalamic stimulation in two rodent models of Parkinson’s disease.

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