The effect of frontal cortex lesion on the activity of the dopaminergic system in rat striatum

Sieklucka-Dziuba, M., Wamil, A., Kleinrok, Z.: The effect of frontal cortex lesion on the activity of the dopaminergic system in rat. striatum. Acta physiol, pol., 1988, 39 (4): 254-260. The experiment was carried out on male Wistar rats weighing 180-220 g with lesion in the cortex of the frontal lobe. The activity of the dopaminergic system was studied by means of behavioural tests such as determination of spontaneous motor activity, apomorphine-induced stereotypy,haloperidol-induced catalepsy. Increased intensity of stereotypy was observed reaching a maximum 14 days after frontal lobe damage. Moreover, a slight tendency was observed lor inhibition of haloperidol-induced catalepsy without changes in the spontaneous motor activity of the animals. Biochemical investigations demonstrated reduced dopamine content in the striatum on the side of the lesion.