The left-handed double helical nucleic acids

The conversion of right-handed dsDNA and dsRNA to the left-handed Z-con - formation in volves a re or ga ni za tion of the nu cleo tides rel a tive to each other. This con- ver sion can be fa cil i tated by the tight bind ing of a Z-conformation-specific pro tein do­main from the ed it ing en zyme dsRNA adenosine deaminase. This may in flu ence the mod i fi ca tion of both pre-mRNAs as well as some replicating RNA viruses.