Effect of acetylsalicylic acid on ROS production in whole blood and milk from healthy and mastitic cows

The aim of this study was to establish the effect of different concentrations of acetylsalicylic acid (ASA) on reactive oxygen species (ROS) production by phagocyting cells. A method of chemiluminescence level measurement was used. Acetylsalicylic acid depressed spontaneous and zymosan-induced chemiluminescence in whole blood samples and in secretion from inflamed udder samples in concentrations of 500 μg/ml and 100 μg/ml. ASA in a concentration of 50 μg/ml increased the chemiluminescence level in whole blood taken from healthy cows.