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Congestive heart failure is a clinical syndrome whose hallmarks are fatigue and dyspnea. Common pathophysiologic features of heart failure include changes in the structure of the left ventricle of the heart, function, and neurohormonal activation. A recapitulation of the heart failure phenotype in a large animal model can make it possible to translate basic science discoveries into clinical therapies. Models of myocardial infarction/ischemia, ischemic cardiomyopatyhy, ventricular pressure and volume overload and pacing- -induced dilated cardiomyopathy have been created for dogs, pigs and sheep to investigate heart failure and potential therapies. This article presents types of large animal models of heart failure, methods of their development and their clinical usefulness.