Wplyw fluoru na aktywnosc dehydrogenazy mleczanowej w hepatocytach szczura

Badano odczyn histochemiczny na aktywność dehydrogenazy mleczanowej [LDH 1.1.1.27] w wątrobach szczurów poddanych działaniu fluorku sodu (NaF). W wyniku przeprowadzonych badań stwierdzono zmiany w aktywności LDH w wątrobach szczurów po podaniu NaF z wodą do picia.

The aim of the study was to evaluate the effect of fluorine on the activity of lactate dehydrogenase (LDH) in rat hepatocytes. Wistar rats (n = 90) were used in the experiment. The animals were divided into 3 groups; the control group was drinking tap water with trace amounts of fluoride, while two other groups received fluoride at 10.6 mg NaF/dm3 and 32.0 mg NaF/dm3, respectively. The rats were exposed to fluoride for 4 months since the intrauterine life to maturity. It has been found that long-term dietary exposure to sodium fluoride leads to changed LDH activity in the rat liver and that the applied fluoride dose affects reversibility of the changes in lactate dehydrogenase activity.