Stezenie mleczanow i glukozy w surowicy krwi oraz glikogenu w watrobie w zatruciu ostrym chlorfenwinfosem

Celem pracy było zbadanie wpływu chlorfenwinfosu, w dawce jednorazowej, na stężenie mleczanów i glukozy w surowicy krwi oraz na obraz glikogenu w wątrobie.

The aim of this work was to estimate the effect of chlorphenvinphos on the concentration of lactate and glucose in blood serum and glycogen in the liver. The test animals received oil alone or oil solution of chlorphenvinphos at 0.5 or 0.1 LD50. The test material was collected at hour 1, 24 and 48 since the exposure. The following were assayed: serum glucpse by the Biochem Test, serum lactate by the Sigma test, and liver glycogen by the histological method. It was found that exposure to a single dose of chlorphenvinphos resulted in reduced number of glycogen granules, vacoulated degeneration of hepatocytes and colliguative necrosis. The changes were more evident in the animals exposed to the higher dose of the pesticide. The acute poisoning with chlorphenvinphos resulted also in hyperglycaemia and lactate acidosis.