Influence of Lydium KPL upon morphology of lung tissue and serum cytokine level in irradiated rats

The modifying influence of Lydium KLP upon the early postirradiation reaction in rats was studied. The effects of Lydium KLP upon the intensity of irradiation reaction was monitored in morphological examinations of the trachea and lung tissue and concentrations of chosen blood plasma proinflammatory cytokines. The experiment was carried out on four groups of Wistar rats: (1) not irradiated (control), (2) administered with Lydium KLP, (3) irradiated and (4) irradiated with Lydium KLP administration. After three months the animals were sacrificed and histopathological examinations of the trachea and lung sections were performed. The concentrations of TNFa, IL-6 chemotactic factor MIP-2 were determined with commercial kits. It was found that postirradiation reduced the damage of the trachea and lung tissue in the group of rats irradiated with simultaneous administration of Lydium KLP. However, the concentrations of proinflammatory cytokines in the group of rats irradiated with simultaneous administration of Lydium KLP were higher in comparison to the group irradiated, not treated with Lydium KLP.