Ochronny wplyw seleninu sodowego na ponitrozowe stany zapalne w watrobie szczura.Cz.I.Zmiany aktywnosci enzymow:GSH-Px,SOD,GAT

Podawanie szczurom zeleninu sodowego ochrania ich wątrobę przed toksycznym działaniem nitrozozwiązków i powoduje wzrost aktywności enzymów antyoksydacyjnych

Experiments were conducted on female Wistar rats intoxicated with nitroso-alpha-naphthol in a dose of 3 mg/kg body weight/day (aqueous solution in drinking water) for 8 month, to investigate the protective effect of sodium selenite (0,5 mg/kg body weight/day) on liver inflammatory state caused in animals by nitroso-naphthol. The controls received drinking water alone. Erythrocyte and liver glutathione peroxidase, superoxide dismutase, and catalase activities were measured at the beginning of tests and after 4 and 8 month. The highest increase of erythrocyte and liver glutathione peroxidase activity was found in the tourse of fourth month of the experiment. Results obtained allow for conclusion that exogenic selenium protects the liver against nitroso- compounds' action, increases selenium-dependent glutathione peroxidase activity, and reduces rat liver damage.