Picosecond laser pulses mediated drug release from magnetoliposomes

Liposomes made from dipalmitoyl-phosphatidylcholine and containing 6-carboxyfluorescein and dextran-magnetite entrapped in their aqueous interior compartments have been irradiated with a picosecond laser pulses. Substantial amounts of carboxyfluorescein were released in response to a single picosecond laser pulse and almost complete release was achieved using four laser pulses, which may be useful for laser induced delivery of therapeutic agents and other applications of lasers in biological systems.