Toksycznosc pestycydow fosforoorganicznych - wplyw na watrobe

Organophosphate insecticides affect health. The effects could be divided into four groups: an acute cholinergic toxicity, organophosphate-induced delayed neuropathy (OPIDN), intermediate syndrome, long-term neuropsychological and neurophysiological effect. Acute organophosphate intoxication may lead to changes in serum enzyme activities indicative of liver damage. Patients acutely intoxicated with organophosphates and hospitalised for that reason showe symptoms of liver damage; disturbed liver functions were observed in workers of plants producing those insecticides. In persons exposed to those compounds, as well as in the experimental animals, the liver damage does not involve the cholinergic mechanism. It is suppesed that reactive oxygen species are involved in that liver damage.