Wystepowanie oraz lekowrazliwosc opornych na karbapenemy szczepow Pseudomonas aeruginosa izolowanych z materialu klinicznego w latach 1998-2009

Przeprowadzono retrospektywną analizę częstości izolacji oraz lekowrażli- wości 775 szczepów Pseudomonas aeruginosa opornych na imipenem i me- ropenem. Szczepy objęte badaniem, pochodzące z materiału od 568 chorych, izolowano w latach 1998-2009 w Zakładzie Mikrobiologii Klinicznej Szpitala Uniwersyteckiego nr 1 im. dr. A. Jurasza w Bydgoszczy. W okresie objętym badaniem odnotowano tendencję wzrostową częstości izolacji szczepów P. aeruginosa o fenotypie oporności na karbapenemy.

P. aeruginosa rods are dangerous pathogens mainly responsible for nosocomial infections of different localization. Resistance to carbapenems, observed among them, is a serious threat due to ability to be transmitted between bacterial species. The aim of our study was to retrospectively evaluate the frequency of isolation and susceptibility to antibiotics of imipenem- and meropenem-resistant P. aeruginosa strains isolated between 1998 and 2009 from patients of University Hospital No 1 of dr A. Jurasz in Bydgoszcz. Study shows increasing number of isolation that type of strains from 19 in 1998 to 144 in 2009. Among all isolated P. aeruginosa strains majority was obtained from patients of the Intensive Care Units, Rehabilitation and Surgery Clinics. Examined strains of P. aeruginosa rods were mainly isolated from urine (20,5%), bronchoalveolar lavage (17,7%) and wound swabs (14,5%) samples. The isolates demonstrated frequently resistance to carbenicillin (≥66,7%), ticarcil- lin (≥72,7%) and cefotaxime (≥75,6%). The lowest rate of resistant strains was observed in case of ceftazidime (≤68,8%), aztreonam (≤47,4%) and Colistin (≤1,7%) suggesting the highest activity of that antimicrobials against infections caused by examined strains.