Wplyw zatrucia ostrego chlorfenwinfosem na aktywnosc enzymow antyoksydacyjnych oraz stezenie dialdehydu malonowego u szczurow

Zbadano wpływ podania chlorfenwinfosu w jednorazowej dużej dawce na aktywność enzymów antyoksydacyjnych i stężenie diadehydu malonowego we krwi szczurów.

The aim of this paper was examination of the influence of chlorfenvinphos on the activity of an antioxidant enzymes in the blood and concentration of the serum malonondialdehyd in rats. It were found increase of the activity of SOD in 24 h and decrease in the 48 h; increase CAT activity, decrease GR activity in the 48 h and increase of G-6-P-DH activity in the 24 and 48 h after intoxication. Activity of GPX did not change statistically significant. It was observed decrease of MDA concentration in the serum in 1 and 24 h after intoxication and return to value in the control groups in the 48 h. It can be concluded that the changes of the activity of enzymes and concentration of MDA in the blood indicates hypoxia in the first period of intoxication (to 24 h) and reoxidation process in the later period.