Effect of Biolex Beta-HP on selected parameters of specific and non-specific humoral and cellular immunity in rats

The experimental material comprised 20 adult Wistar rats aged 12 weeks, divided into two equal groups (control and experimental) including five males and five females each. From the first day of the experiment, the experimental group was fed Murigran feed supplemented with ß-l,3/l,6-D-glucan (Biolex Beta-HP) at a dosage of 12-19 mg/rat/d, depending on body weight, while the control animals were administered the same feed without any additives. On days 1 and 14 of the experiment, arterial blood samples were collected and diluted with heparin, and then the following parameters were determined: total protein and γ-globulin contents, lysozyme and ceruloplasmin activities, the proliferative response of blood lymphocytes after stimulation with LPS or ConA, metabolic activity, and the potential killing activity of phagocytes. The results showed that Biolex-Beta HP modulated the selected parameters of specific and non-specific humoral and cellular immunity in rats.