In vivo effect of 2-deoxy-D-glucose on adenine nucleotide levels in the liver and skeletal muscle of rats

Torlińska T., Rutkowska D., Hryniewiecki T., Paluszak J.: In vivo effect of 2-deoxy-D-glucose on adenine nucleotide levels in the liver and skeletal muscle. Acta Physiol. Pol. 1990, 41 (7): 75-83. The present report indicates that 2-deoxy-D-glucose (2-DG) at a single dose causing reduction of Т„ has no influence on liver and skeletal muscle content of ATP, ADP and AMP, the ATP/ADP ratio, energy charge potential (ECP) and total adenine nucleotides (TAN). After administration of 2-DG for 3) successive days, the level of ATP, ATP/ADP ratio, the values of ECP and TAN are decreased both in the liver nad skeletal muscle. However, 72 hours after the last injection of 2-DG adenine nucleotide contents returned to the values observed in control group, indicating that the in vivo effect of this glucose analogue is fully reversible.