Development of innovative biopolymers designed for bone regeneration applications and in vitro study of their biocompatibility and osteogenic capacity on human bone marrow mesenchymal stem cells

In the frame of a project aiming to the improvement of the properties of biodegradable polyester-based devices, designed for bone regeneration, we have prepared and characterized novel composites based on poly(ε-caprolactone) (PCL). In particular, we report in this paper the functional changes made through radical grafting on PCL to obtain the less hydrophobic derivatives, PCL-MA-GMA [maleic anhydride (MA)-glycidylmethacrylate (GMA)] and PCL-DMAEA [N-(dimethyl-amino)ethylacrylate]. In addition, we studied in vitro the biocompatibility and the osteogenic capacity of these novel polyesters on human bone marrow (BM) mesenchymal stem cells (MSC).