Compartmental model of the pharmacokinetics of drugs excreted by bile or by non-renal mode

The theoretical biology analysis, uses mathematical and physical models and bioinformatics tools in practical medicine. The analysis in silico reduces time and costs of new designed drugs and provides wider spectrum of information for exploration. Moreover, bioinformatics analysis of genome and proteome, especially with the use of microarray allows specifying diagnosis and therapy. The methods enabling precise preparation of therapy by means of accurate medicine dosage are being currently searched, such an approach permits to increase the effectiveness of therapy, eradicate side effects (i.e. medicine overdosing), reduce the total cost of therapy and cut down its interval. The elaborated model involves the partition of human body into compartments having different physical features: weight and volume, or physiological character: metabolic efficiency, penetration rate of drug. Additional parameters can be introduced to the model: Wa/b, Wwzb and λ. Due to the nature of simulation each individual case can be run with high precision. The model is implemented in the GROW_4 virtual environment which is accessible free of charge on the websites: www.sitcome.vacau.com or www.uwm.edu.pl/bioinfo (in science/projects/grow).