The effect of hydroxyapatite coating with silver nanoparticles on osseointegration of titanium implants

During the implantation surgery, an infection associated with the biofilm formation may occur. Both the type of the introduced material as well as the implant osseointegration largely determine the effectiveness of bone defect treatment. The materials research is increasingly focusing on improving the osseointegration process. A bacterial biofilm can form on any surface of the artificial organ that has been introduced into the body or surrounding tissues. A bacterial infection is one of the most serious complications of implantology surgery leading to serious physiological damage. As proved in the literature, a solution that can prevent bacterial infections is to modify the implant surface by applying an antibacterial coating, while maintaining the material biocompatibility. The article presents the tests results of prototype implants with hydroxyapatite coatings obtained via plasma spraying on titanium surfaces. The resulting coatings were enriched with silver nanoparticles, the content of which was about 2%. The animal model are New Zealand rabbits. The implants were placed in the femur of the animal. The amount of released ions and the force of pulling the implants from the bone were determined. The binding strength between the joint surface and the implant was determined by the mechanical blocking and biological binding of growing bone tissue. In addition, the surface structure of the obtained implants was evaluated. It has been shown that the surface modification of the implants affected the obtained stabilization value, as compared to the implants surface coated only with hydroxyapatite.

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Opracowanie rekordu ze środków MNiSW, umowa Nr 461252 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2020).