Fungicidal activity of alkaloid from Colchicum species and its complexes

The colchicine complexes with Na+ , K+ Mg2+ and Ca2+ cations of sulphates and carbonates have been synthesized and were tested against fungicidal activity. The obtained complexes were tested to determined minimal inhibitory concentration (MIC) and minimal fungicidal concentration (MFC) against microfungi using 96-well microtiter plate-based method. The colchicine itself wasn’t active against most of used microfungi with the exception of A. pullulans. Colchicine complexes with K2CO3 and MgSO4 inhibited growth the majority of tested microfungi.

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Opracowanie rekordu ze środków MEiN, umowa nr SONP/SP/546092/2022 w ramach programu "Społeczna odpowiedzialność nauki" - moduł: Popularyzacja nauki i promocja sportu (2022-2023).