Computer modelling of vascular systems

A model of the vascular system perfusing an internal organ is presented in the paper. The system's development is driven by the increasing needs of growing tissue. The modelled network consists of 2 or 3 (in the case of the liver) vascular trees connected on the macro-cell level. Each appearance of a new macro-cell activates an angiogenic process. The geometry of newly formed vessels is determined as a result of local optimization of the bifurcation volume. The model can simulate modifications of the vascular network caused by pathological processes.