Synthesis, Spectral Properties and Antitumor Activity of Some Transition Metal Complexes with a Schiff Base Ligand

Four complexes of transition metals, namely: [Mn(L)2] (complex 1), [Ni(L)2ź0.5H2O] (complex 2), [Cu(L)2ź4H2O] (complex 3) and [Zn(L)2ź0.5H2O] (complex 4), (L = Schiff base derived from trimethylol amino methane and salicylic aldehyde), have been synthesized. The complexes were characterized by elemental analysis, IR, 1H NMR, UV and TG-DTA spectra. Tentative structures for the complexes have been proposed. The antitumor activity against HL-60 human leukemia cells of free ligand and its Mn, Ni, Cu complexes were studied by MTT method.