Transition Metal Manganese(II), Nickel(II), Copper(II) and Zinc(II) Complexes of a New Schiff Base Ligand: Synthesis, Characterization and Antitumor Activity Studies

Four transition metals complexes ([Mn(L)2] (complex 1), [Ni(L)20.5H2O] (complex 2), [Cu(L)24H2O] (complex 3) and [Zn(L)20.5H2O] (complex 4)), which contain a new Schiff base ligand (HL) derived from 2,4-dihydroxylacetophenone with triaminotriethylamine, have been synthesized and subsequently characterized by element analysis, 1HNMRand mass spectra. Their properties have been investigated by IR, UV and TG-DTA techniques. Tentative structures for the complexes have been proposed based on the experimental results. The antitumor activity against HL-60 human leukemia cells of free ligand (L) and its Mn(II), Ni(II), Cu(II) complexes were also studied by MTT method. The Ni(II) complex shows the best antitumor activity properties among these complexes.