1-(2,4-Dinitrophenyl)-5-nitrouracil a Versatile Reagent for the Synthesis of N1-Modified Uracil Derivatives

1-(2,4-Dinitrophenyl)-5-nitrouracil has been used as a substrate in reactions with a number of compounds possessing primary amino groups such as: amino alcohols, aminodiols, esters of amino ac ids and benzylamines. As a result of regioselective course of performed reactions the series of 5-nitro-1-substituted uracils were obtained. All newly synthesized compounds were subjected to primary bioactivity as says as inhibitors against Mycobacterium tuberculosis; two of them exhibited inhibition ability.