Hemocompatibility of ultrafine systems on the basis of chitosan and its derivatives polymer-colloid complexes

This article presents the results of the development process for the preparation of micro and nano-sized polymer-colloid complexes (РСС) on the basis of water-soluble natural polymer chitosan (СTZ) and the sodium salt of chitosan succinylamid (SСTZ) with silver halide sols in aqueous media. Results of research of СTZ, sodium salt of SСTZ solutions and PСС of CTZ and SСTZ with colloidal particles of silver iodide influence on structurally-functional properties of erythrocytes’ membranes on model of acidic hemolisis are presented in the article. Their influence on the nature of erythrocytes distribution by degree of their stability and on kinetic parameters (the beginning, intensity and completion of process of their destruction) under the influence of the damaging agent (HCl) is shown. The comparative analysis of results convinces that СTZ, SСTZ solutions and disperse systems on the basis of PСС of СTZ and SСTZ with colloidal particles of the silver iodide are capable of modulating variously matrix properties of erythrocytes of blood.