In vitro study of chemically modified carbon fibres

The objects of this study were three types of low-carbonised carbon fibres. The fibres differed in oxygen contents and in surface state resulting from chemical bonding. The behaviour of macrophages line J774 and peritoneal mouse macrophages in the presence of these fibres was studied. Viability, ability to proliferation and releasing level of IL-6 and NO were analysed. It has been shown that a/l examined fibres in- duce the formation of considerable high level of IL-6. Moreover, none of the analysed materials induced of NO forming. Macrophage viability varied depending on oxygen content on the carbon surface. Reaction of cells with modified surface carbon fibres brings about significant/y different cells response in vitro.