Synthesis and structural evolution of 2-[N-Boc-5-aminopentyl]-2-oxazoline-based copolymers: from protected precursors to amino-functional materials

The essence of this work is to gain deep insight into the polymerization of [N-Boc-5-aminopentyl]-2-oxazoline and the characterization of the obtained polymers before and after deprotection. Here, a series of microwave-assisted CROP reactions of 2-[N-Boc-5-aminopentyl]-2-oxazoline were carried out. Efforts were made to synthesize copolymers with a high DP for PentNH_BocOx, reaching up to 100. For the first time, copolymers composed of PentNH_BocOx and EtOx with identical compositions but differing microstructures (block and random) have been successfully obtained. Initially, the absolute molar masses of the protected copolymers were determined, and the solution behavior of the PentNH_BocOx-based copolymers was thoroughly investigated. The quantitative removal of Boc-protective groups from the macromolecules was confirmed by spectroscopic methods, followed by polymer desalination. Newly, the behavior of copolymers containing PentNH₂Ox units in solutions has been studied. The influence of PentNH₂Ox-based copolymers on the viability of human skin fibroblasts over a wide range of concentrations was analyzed. For a model copolymer containing amino groups, a chelating compound was attached to evaluate the suitability of these systems for potential antibacterial applications. 

The dataset includes tabular files as well as images in JPG and TIF formats.