Wolnorodnikowe mechanizmy biochemicznej obrony żywiciela

The mechanism of intracellular killing of pathogens which involves both oxygen and reactive nitrogen intermediates have been discussed. The attention is focused on inducible nitric oxide synthase which produces NO, a soluble free radical. The role of nitric synthase in the pathogenesis of many parasitic infections has recently been emphasised. The participation of enzymatic and non-enzymatic antioxidants in the pathogenesis of many infections and the role of proteasomes in the process of repair of the oxidetively damaged proteins are also discussed.