Wpływ preparatów stosowanych w zwalczaniu choroby motylicznej na gospodarkę witaminami z grupy B oraz na obraz histologiczny i histochemiczny narządów wewnętrznych u szczurów. II. Bilevon 9015 "Bayer"

Effect of maximum tolerant dose of Bilevon 9015-Bayer on the histological and histochemical changes in the internal organs and on the level of the vitamin B₂, B₁₂ and PP in the liver of the rats was studied. It was shown that Bilevon 9015-Bayer caused not only the morphological changes in the duodenum (oedema villi) and in the kidney (extravasations), but also produced the stress reaction that was expressed by the decrease of the glycogen content in the liver and the depletion of lipids in the inner layers of the adrenal cortex. Although the toxic effect was still seen after 72 hours, but it was transient and no changes were found on the 7th day of the experiment. This effect was not probably caused by the properties of the drug, but by the dose used in the experiment. No significant changes in the level of the examined vitamins in the liver could be seen.