Development of methods and technologies of informatics for process modeling and management * Tools of informatics in environmental engineering * Method of valuation by order theory applied on the environmental topie of data-availability of pharmaceutically active substances

Bibliography p. 119-120

[1-5], 107-120 pages ; 21 cm

[1-5], 107-120 stron ; 21 cm

Reports on pharmaceuticals and personal care products (PPCPs) have raised substantial concern in the public concerning drinking water and reclaimed wastewater quality issues. Targeted ecotoxicological studies are lacking a/most entirely and such investigations are needed focusing on subtle environmental effects. This will allow better and comprehensive risk assessments of pharmaceuticals in the future (Fent et al. , 2006). In our last year 's contribution to the conference "Applications of lnformatics in Environment Engineering and Medicine " (Voigt et al., 2005a) we presented the results of an intensive literature study on selected pharmaceuticals which were detected in the water environment. As concluded in the study the data availability on pharmaceuticals should be scrutinized. Hence follows the urgent need for evaluation of the data-availability on pharmaceuticals in environmental and chemical databases. A data-matrix consisting of 22 databases and 16 pharmaceuticals is set-up. The consideration of the chosen pharmaceutical in databases x is coded O = not available, or l = available. The mathematical evaluation method applied in this approach is named METEOR (Method of Evaluation by Order Theory) and has its origin in discrete mathematics. METEOR is used for aggregation and weighting procedures of data-matrices. The basic idea is that subsets of the information base IB can be combined by weighted sums, where the weights are the components of the tupie g. Severl logical aggregations of pharmaceuticals will be demonstrated. All approaches show that the datasituation on the chosen test-set of 16 well-known and high produced pharmaceuticals is far from being satisfactory. The issuse of pharmaceuticals in the environment and the unavailability of data necessitate much closer communication between science and medical healthcare and politicians.

Bibliografia s. 119-120