Early damage of the central nervous system in experimental poisoning with manganese compounds

Early morphological alterations of the central nervous system in rats due to manganese chloride intoxication were characterized. The animals were intoxicated in the course of 4 weeks by intravenous administration of manganese chloride in a total dosis of 240 g Mn++/kg of body weight. The animals were killed either immediately or 7 days after the last injection of the toxic substance. The morphological abnormalities of the central nervous system were compared with thosefound in animals surviving 1 month after intoxication (Mossakowski et al. 1982).