Electron microscopic observations on experimental cerebral ischemia in immature and adult rats

Glycogen accumulation in the C.N.S. is one of the earliest and most sensitive symptoms of anoxic and ischemic impairment of nervous tissue (Mossakowski et al.: J. Neuropath. Exp. Neurol. 27, 500, 1968; Mossakowski and Zelman: Postępy Astronautyki, Suppl. 1, 37, 1971). Partial brain ischemia produced by bilateral ligation of the com-mon carotid arteries causes significant glycogen deposition with rarely occurring morphological changes. The aim of the present work was to localize the glycogen deposits at the ultrastructural level in immature and adult brains, and to describe the remaining ultrastructural changes produced by bilateral ligation of the carotid arteries.