Intravascular coagulation in hyperacutely rejected liver xenografts

In order to investigate whether the cessation of blood flow in a rabbit-to-dog liver graft is due to enzymatically induced intravascular coagulation in the transplant, 2 experiments were carried out. The gradient of coagulation factors across the graft was measured during the rejection. No consumption of fac¬tors V,VII, and X was found. There was retention of 11° of inflowing fibri¬nogen, and prolongation of calcium clotting time by 30 sec, and thrombin time by 60sec. Nonetheless, blood flow stopped in the organ with in 5—7 minutes.