Tytuł pozycji:
Nasal versus bronchial and nasal response to oral aspirin challenge : clinical and biochemical differences between patients with aspirin-induced asthma/rhinitis
Background: Aspirin-induced asthma/rhinitis (AIAR) is characterized by the altered metabolism of leukotrienes and proinflammatory prostaglandins. The basal and postchallenge levels
of eicosanoids might reflect the clinical and biochemical characteristics of patients with distinct types of hypersensitive
responses to aspirin.
Objective: We compared clinical and eicosanoid profiles of
patients with AIAR showing both bronchial and nasal versus
isolated nasal responses to aspirin challenge.
Methods: Twenty-three patients with AIAR underwent the single-blind, oral, placebo-controlled aspirin challenge. The
bronchial response (BR) was evidenced by dyspnea and
spirometry, whereas the nasal response (NR) was evidenced by
nasal symptoms and acoustic rhinometry and/or rhinomanometry. Urinary leukotriene E4 (uLTE4), serum and urinary stable prostaglandin D2 metabolite, and 9α,11β-prostaglandin F2
(9α,11β-PGF2), were determined at baseline and after the
aspirin challenge.
Results: Fifteen subjects showed BR and NR (BNR), whereas 8
showed NR only. Basal uLTE4 in the BNR group was significantly higher than in the NR group. After aspirin challenge, it
increased significantly in both groups. Serum 9α,11β-PGF2
increased after aspirin challenge in the BNR group only. The
patients with BNR had more severe AIAR.
Conclusions: BNR to aspirin in AIAR indicates a more
advanced disease and more profound underlying eicosanoid
metabolism disturbances.