Antiarrhythmic activity of novel S-enantiomers of pyrrolidin-2-one derivatives with adrenolytic properties

A six new analogs of MG-1(S), 1-[2-hydroxy-3-(4-phenyl-1-piperazinyl)propyl]-pyrrolidin-2-one, with adrenolytic properties were tested for electrocardiographic and antiarrhythmic activity in model ventricular arrhythmias associated with coronary artery occlusion and reperfusion in the non-working isolated perfused rat heart and additionally in barium chloride - induced arrhythmia in vivo. All tested compounds slightly decreased the heart rate, prolonged P-Q, Q-T intervals and QRS complex. The antiarrhythmic effects of all tested compounds were weaker than the reference compound MG-1(S).